Manishi Bansal1, Smriti Gupta2, Girdhar Gopal3, Ankush Jindal4
Departments of 1Radiotherapy, 2Pathology and 3Oncosurgery, Mayo Hospital, Mohali; 4Government Medical College and Hospital, Chandigarh, India.

Background: Isolated splenic involvement in non-Hodgkin’s lymphoma is a rare clinical entity and is termed as primary splenic lymphoma (PSL). In such cases, the disease is mostly confined to spleen and splenic hilar lymph nodes. It usually presents with dragging pain in left side of abdomen and huge splenomegaly is detected on investigations. Splenectomy is the main modality of treatment followed by chemotherapy with or without radiation. Case Report: We present a rare case of PSL treated successfully at our institution with splenectomy and chemotherapy. Conclusion: Primary splenic lymphoma is a rare splenic neoplasm. Immunohistochemistry markers are helpful in confirming the diagnosis. Splenectomy is both diagnostic and therapeutic in such cases.